Advances in Diagnostic Adjuncts for Oral Squamous Cell Carcinoma

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Advances in Diagnostic Adjuncts for Oral Squamous Cell Carcinoma

Oral cancer is the 8 th most common cancer in males and the 15 th most common in females in the United States. Each year, it affects approximately 22,000 Americans and results in approximately 5300 deaths. The five-year survival rate of oral cancer remains low (53% to 60%) for the past three decades and delayed diagnosis has been suggested to be one of the major reasons. The detection and diagn...

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Clinical decision support system, a potential solution for diagnostic accuracy improvement in oral squamous cell carcinoma: A systematic review

BACKGROUND AND AIM: Oral squamous cell carcinoma (OSCC) is a rapidly progressive disease and despite the progress in the treatment of cancer, remains a life-threatening illness with a poor prognosis. Diagnostic techniques of the oral cavity are not painful, non-invasive, simple and inexpensive methods. Clinical decision support systems (CDSSs) are the most important diagnostic technologies used...

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Immunohistochemical Evaluation of Fascin in Oral Squamous Cell Carcinoma

Background and purpose: Squamous cell carcinoma (SCC) is the eighth most common cancer in men and the fifteenth in women. Localized recurrence and metastasis to regional lymph nodes are major problems in these patients. Fascin is a 55- kDa protein from the family of actin-binding proteins that is expressed in cells with membranous bronchial tubes. The aim of this study was to evaluate the expre...

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The Cancer Stem Cell Hypothesis in Oral Squamous Cell Carcinoma: A New Target for the Treatment

Within a single tumor clone, cells have significantly different abilities to proliferate and form new tumors. This has led to the hypothesis that most cells in a cancer have a limited ability to divide and only a small subset of distinct cells, the cancer stem cells (CSCs), has the capacity to self-renew and form new tumors . It has been proposed that the development of tumors is based exclusiv...

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Serum Endostatin Levels in Oral Squamous Cell Carcinoma

Introduction: Endostatin is a C-­terminal proteolytic fragment of collagen XVIII and, as with angiostatin and thrombospondin, is known as an anti­angiogenic agent. The aim of this study was to assess the level of serum endostatin in patients with oral squamous cell carcinoma (SCC), and its association with the clinicopathological characteristics of the tumor.   Materials and Methods:  Using an ...

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ژورنال

عنوان ژورنال: The Open Pathology Journal

سال: 2011

ISSN: 1874-3757

DOI: 10.2174/1874375701105010003